🧬 Why the Physical Structure of the Genome May Confound AI
The traditional view of the genome as a static "blueprint" is being called into question. The genome is a dynamic recursive system that utilizes chromatin loops and transcriptional hubs to regulate genes.
🌍 This requires a transition from purely sequence-based models to architectures that account for the three-dimensional topology of chromatin (TADs) and the dynamic environment of the cell.
👤 Understanding biology as a physical system helps to recognize the limitations of current AI breakthroughs and opens the path to treatments through the manipulation of DNA structure.
Source 1: https://www.quantamagazine.org/why-the-human-genomes-tangled-physicality-may-confound-ai-20260618/